NCHR Comments on Hormone Therapy in Postmenopausal Women for the Primary Prevention of Chronic Conditions

May 16, 2022. The currently available evidence on hormone therapy is very clear: Whether combination therapies of estrogen and progestin or treatments with estrogen alone, the risks by far outweigh the limited benefits for postmenopausal women. We thus strongly support USPSTF’s “D” grade recommendation against the use of combined estrogen and progestin for the primary prevention of chronic conditions such as cardiovascular disease, types of cancer, and osteoporotic fractures in postmenopausal persons, as well as the “D” grade recommendation against the use of estrogen alone in postmenopausal persons who have had a hysterectomy.

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Hormone Therapy and Menopause

The experts at the U.S. Preventive Services Task Force issued a clear recommendation: post-menopausal women should NOT take hormones to prevent chronic health conditions, such as increasing bone strength to avoid fractures. The reason is that the risks of these hormones outweigh the benefits. In addition, hormone therapy for menopause increases the risk of breast cancer and the recurrence of breast cancer.

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